Ciencias de la vida y de la materia Centenario de la Gripe Española de 1918

Peter Palese: "Pasos hacia una vacuna universal frente al virus de la gripe"

28/09/2018

Peter Palese, Icahn School of Medicine at Mount Sinai.\nDespite FDA-approved vaccines and antivirals, seasonal and pandemic influenza remain serious threats associated with substantial morbidity and mortality. While annual seasonal influenza virus vaccination is frequently effective albeit underutilized in most countries a safe universal influenza virus vaccine providing broad and long-lasting immunity would represent a major breakthrough. We have developed vaccine constructs which express hemagglutinins resulting in the redirection of the immune response away from the immunodominant (variable) epitopes of the hemagglutinin towards conserved domains of the hemagglutinin and the highly conserved neuraminidase. Such vaccine constructs work well in animal challenge models and are currently tested in clinical trials in humans. The mechanism by which these novel vaccines mediate protection is via antibodies which do not rely on hemagglutination inhibitory (HI) activity but rather on ADCC (antibody-dependent cell-mediated cytotoxicity) effects, activation of complement and/or inhibition of virus replication through directly binding to viral proteins. It is hoped that the universal influenza virus vaccine based on novel hemagglutinin constructs will provide long-lasting protection against all seasonal and pandemic influenza virus strains in the future.

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Vídeos
Ciencias de la vida y de la materia Centenario de la Gripe Española de 1918

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Inmaculada Casas: "El virus de la gripe y sus infecciones anuales"

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Peter Palese: "Pasos hacia una vacuna universal frente al virus de la gripe"

28/09/2018